Cryo-EM maps how p97 and its partner proteins coordinate protein disposal

Researchers at the University of Münster, working with colleagues at the University of Duisburg-Essen, have visualised how the protein machine p97 cooperates with three partner proteins, Ufd1, Npl4 and FAF1, as it handles a target protein. Their structures suggest that the components continually adjust to one anothe…