PD-1 disrupts CD28 signalling condensates, guiding redesign of CAR-T cells

Researchers in China have shown that the costimulatory receptor CD28 forms signalling condensates with the kinase Lck, and that the inhibitory receptor PD-1 can break these condensates apart. CAR-T cells carrying CD28 mutants that evade PD-1 were less suppressed in laboratory tests and performed better than wild-typ…